>>Unitest Dengue Rapid Test Device (Whole Blood)

For Asia, Africa and Latin American markets only

The Dengue IgG/IgM Rapid Test Strip is a qualitative membrane-based immunoassay for the detection of Dengue antibodies in whole blood. This test consists of two components, an IgG component and an IgM component. In the IgG component, anti-human IgG is coated in test line region 1 of the test. During testing, the specimen reacts with Dengue-antigen coated particles in the test device. The mixture then migrates upward on the membrane chromatographically by capillary action and reacts with the anti-human IgG in test line region 1. Ifthe specimen contains IgG antibodies to Dengue, a colored line will appear in test line region 1. In the IgM component, anti-ligand is coated in test line region 2 of the test. During testing, the specimen reacts with ligand anti-human is coated in test line region 2 of the test. During testing, the specimen reacts with ligand anti-human IgM. Dengue IgM antibodies, if present in the specimen, reacts with the ligand anti-human IgM and the Dengue antigen-coated particles in the test device, and this complex is ceptured by the anti-ligand, forming a colored line in test line region 2.

Therefore, if the specimen contains Dengue IgG antibodies, a colored line will appear in test line region 1. If the specimen contains Dengue IgM antibodies, a colored line will appear in test line region 2. If the specimen does not contain Dengue antibodies, no colored line will appear in either of the test line regions, indicating a negative result. to serve as a prodedural control, a colored line will always change from red to blue in the control line region, indicating that the proper volume of specimen has been added and membrane wicking has occurred.

TEST PROCEDURE

**"This product is not distributed in the European Union. It does not bear the CE marking as it has not undergone the conformity assessment procedures of the European Directive 98/79/EC, for in vitro medical devices".

Dengue Fever
 

What is Dengue fever?

Dengue Fever is an acute viral disease characterized by sudden onset of fever for 3-5 days, with intense headache, joint and muscle pain, pain behind the eyes, nausea, gastrointestinal disturbances and rash. Minor bleeding, such as gum and nose bleeding, may occur at any time during the febrile phase. Children usually have a milder disease than adults. The incubation period is 3 to 14 days. Recovery may be followed by prolonged fatigue and depression. Occasionally, the disease may progress to Dengue Heamorrhagic Fever (DHF) with bleeding and shock, leading to death. Travellers to tropical countries, especially in Southeast Asia and Latin America, may be at risk of dengue infection. Epidemics usually occur during and shortly after the rainy season.

How does it spread?

Dengue virus is transmitted to human by mosquitoes, especially Aedes aegypti and Aedes albopictus. This is a day-biting species with increased biting activities for 2 hours after sunrise and several hours before sunset. Patients are usually infective for mosquitoes from shortly before to the end of the febrile period, an average of about 6-7 days. It cannot be directly transmitted from person to person.

How can you prevent it?

At present, there is no effective vaccine for dengue, so travellers must rely on preventing mosquito bites to combat infection (especially during their high biting activity time). The personal protection measures against mosquito bites are as follows:

• Wear long-sleeved shirts and trousers;

• Rest in air-conditioned or well-screened rooms;

• Use aerosol insecticide indoor and use bednets if sleeping areas are not air-conditioned or screened.

• Use insect repellents containing DEET (for children keep DEET concentration below 20%) on exposed skin;

• If travelling in endemic rural areas, carry a portable bed-net and apply permethrin on it as well as to clothes.

How is it treated?

Anyone returning from travel to a dengue-infected area and then falling sick within one month, especially with bleeding signs, should seek medical assistance immediately. High fever should be treated by sponging and the appropriate use of paracetamol. Do not take aspirin because they can lead to bleeding and cause stomach irritation. There is no specific treatment available for treating DHF. Supportive measures have to be provided in hospital.

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